Comparison of the clinical prediction model PREMM(1,2,6) and molecular testing for the systematic identification of Lynch syndrome in colorectal cancer

BACKGROUND: Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history. OBJECTIVE: To compare strategies using PREMM(1,2,6) and tumour testing (microsatellite instability...

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Bibliografiska uppgifter
Huvudupphovsmän: Kastrinos, Fay, Steyerberg, Ewout W, Balmaña, Judith, Mercado, Rowena, Gallinger, Steven, Haile, Robert, Casey, Graham, Hopper, John L, LeMarchand, Loic, Lindor, Noralane M, Newcomb, Polly A, Thibodeau, Stephen N, Syngal, Sapna
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470824/
https://ncbi.nlm.nih.gov/pubmed/22345660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-301265
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