Development and Validation of the PREMM(5) Model for Comprehensive Risk Assessment of Lynch Syndrome

PURPOSE: Current Lynch syndrome (LS) prediction models quantify the risk to an individual of carrying a pathogenic germline mutation in three mismatch repair (MMR) genes: MLH1, MSH2, and MSH6. We developed a new prediction model, PREMM(5), that incorporates the genes PMS2 and EPCAM to provide compre...

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Pubblicato in:J Clin Oncol
Autori principali: Kastrinos, Fay, Uno, Hajime, Ukaegbu, Chinedu, Alvero, Carmelita, McFarland, Ashley, Yurgelun, Matthew B., Kulke, Matthew H., Schrag, Deborah, Meyerhardt, Jeffrey A., Fuchs, Charles S., Mayer, Robert J., Ng, Kimmie, Steyerberg, Ewout W., Syngal, Sapna
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2017
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493047/
https://ncbi.nlm.nih.gov/pubmed/28489507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2016.69.6120
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