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Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management

BACKGROUND: Lynch syndrome (LS) is associated with a high risk for colorectal cancer (CRC) and extracolonic malignancies, such as endometrial carcinoma (EC). The risk is dependent of the affected mismatch repair gene. The aim of the present study was to calculate the cumulative risk of LS related ca...

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書誌詳細
主要な著者: Ramsoekh, Dewkoemar, Wagner, Anja, van Leerdam, Monique E, Dooijes, Dennis, Tops, Carli MJ, Steyerberg, Ewout W, Kuipers, Ernst J
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804564/
https://ncbi.nlm.nih.gov/pubmed/20028567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-7-17
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