Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management

BACKGROUND: Lynch syndrome (LS) is associated with a high risk for colorectal cancer (CRC) and extracolonic malignancies, such as endometrial carcinoma (EC). The risk is dependent of the affected mismatch repair gene. The aim of the present study was to calculate the cumulative risk of LS related ca...

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Main Authors: Ramsoekh, Dewkoemar, Wagner, Anja, van Leerdam, Monique E, Dooijes, Dennis, Tops, Carli MJ, Steyerberg, Ewout W, Kuipers, Ernst J
格式: Artigo
語言:Inglês
出版: BioMed Central 2009
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804564/
https://ncbi.nlm.nih.gov/pubmed/20028567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-7-17
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