Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

Sterol 14α-demethylase (14DM, the CYP51 family of cytochrome P450) is an essential enzyme in sterol biosynthesis in eukaryotes. It serves as a major drug target for fungal diseases and can potentially become a target for treatment of human infections with protozoa. Here we present 1.9 Å resolution c...

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Main Authors: Lepesheva, Galina I., Park, Hee-Won, Hargrove, Tatiana Y., Vanhollebeke, Benoit, Wawrzak, Zdzislaw, Harp, Joel M., Sundaramoorthy, Munirathinam, Nes, W. David, Pays, Etienne, Chaudhuri, Minu, Villalta, Fernando, Waterman, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804335/
https://ncbi.nlm.nih.gov/pubmed/19923211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.067470
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