Elimination of both CD4(+) and CD8(+) T cells but not B cells eliminates inflammation and prolongs the survival of TGFβ1-deficient mice

Transforming growth factor β1 (TGFβ1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1(−/−) mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells...

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Hlavní autoři: Bommireddy, Ramireddy, Engle, Sandra J., Ormsby, Ilona, Boivin, Gregory P., Babcock, George F., Doetschman, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804065/
https://ncbi.nlm.nih.gov/pubmed/15922720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2005.02.004
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