Elimination of both CD4(+) and CD8(+) T cells but not B cells eliminates inflammation and prolongs the survival of TGFβ1-deficient mice

Transforming growth factor β1 (TGFβ1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1(−/−) mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells...

Full description

Saved in:
Bibliographic Details
Main Authors: Bommireddy, Ramireddy, Engle, Sandra J., Ormsby, Ilona, Boivin, Gregory P., Babcock, George F., Doetschman, Thomas
Format: Artigo
Language:Inglês
Published: 2005
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804065/
https://ncbi.nlm.nih.gov/pubmed/15922720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2005.02.004
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items