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TGFβ1 deficiency does not affect the generation and maintenance of CD4(+)CD25(+)FOXP3(+) putative T(reg) cells, but causes their numerical inadequacy and loss of regulatory function

TGFβ1 is considered to be required for peripheral maintenance of CD4(+)CD25(+)FOXP3(+) T(reg) cells. However, we demonstrate no reduction in the percentage of such Tcells in the spleens and thymi of Tgfb1(−/−) mice. Although putative T(reg) cells, characterized as CD4(+)CD25(+)FOXP3(+)CD62L(+) Tcell...

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Detalhes bibliográficos
Main Authors: Bommireddy, Ramireddy, Babcock, George F., Singh, Ram R., Doetschman, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2387055/
https://ncbi.nlm.nih.gov/pubmed/18308639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2007.12.008
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