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TGF-β, T-cell tolerance and anti-CD3 therapy

Recent studies by Chatenoud and co-workers suggest that non-mitogenic F(ab′)(2) fragments of anti-CD3 antibodies, which cannot bind the Fc receptor, induce a prolonged period of tolerance and prevent diabetes in nonobese diabetic (NOD) mice. Tolerance is established by regulatory T cells through the...

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Detalhes bibliográficos
Main Authors: Bommireddy, Ramireddy, Doetschman, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796480/
https://ncbi.nlm.nih.gov/pubmed/14720578
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