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Elimination of both CD4(+) and CD8(+) T cells but not B cells eliminates inflammation and prolongs the survival of TGFβ1-deficient mice
Transforming growth factor β1 (TGFβ1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1(−/−) mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804065/ https://ncbi.nlm.nih.gov/pubmed/15922720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2005.02.004 |
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