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Self-antigen recognition by TGFβ1-deficient T cells causes their activation and systemic inflammation
To investigate whether the multifocal inflammatory disease in TGFβ1-deficient mice is caused by self-antigen (self-Ag)-specific autoreactive T cells, or whether it is caused by antigen independent, spontaneous hyperactivation of T cells, we have generated Tgfb1(−/−) and Tgfb1(−/−) Rag1(−/−) mice exp...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2291532/ https://ncbi.nlm.nih.gov/pubmed/16865088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.3700460 |
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