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Self-antigen recognition by TGFβ1-deficient T cells causes their activation and systemic inflammation

To investigate whether the multifocal inflammatory disease in TGFβ1-deficient mice is caused by self-antigen (self-Ag)-specific autoreactive T cells, or whether it is caused by antigen independent, spontaneous hyperactivation of T cells, we have generated Tgfb1(−/−) and Tgfb1(−/−) Rag1(−/−) mice exp...

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Autores principales: Bommireddy, Ramireddy, Pathak, Leena J, Martin, Jennifer, Ormsby, Ilona, Engle, Sandra J, Boivin, Gregory P, Babcock, George F, Eriksson, Anna U, Singh, Ram R, Doetschman, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291532/
https://ncbi.nlm.nih.gov/pubmed/16865088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.3700460
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