The major adduct of the antitumor drug cis-diamminedichloroplatinum(II) with DNA bends the duplex by approximately equal to 40 degrees toward the major groove.

Eitemau Tebyg

• Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II).
  gan: Yarema, K J, et al.
  Cyhoeddwyd: (1995)
• Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro.
  gan: Poirier, M C, et al.
  Cyhoeddwyd: (1982)
• Ethidium bromide changes the nuclease-sensitive DNA binding sites of the antitumor drug cis-diamminedichloroplatinum(II).
  gan: Tullius, T D, et al.
  Cyhoeddwyd: (1982)
• DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent
  gan: Stehlikova, Kristyna, et al.
  Cyhoeddwyd: (2002)
• Alteration and activation of sequence-specific cleavage of DNA by bleomycin in the presence of the antitumor drug cis-diamminedichloroplatinum(II).
  gan: Mascharak, P K, et al.
  Cyhoeddwyd: (1983)