The major adduct of the antitumor drug cis-diamminedichloroplatinum(II) with DNA bends the duplex by approximately equal to 40 degrees toward the major groove.

We used gel electrophoresis methods to show that reaction of DNA with cis-diamminedichloroplatinum(II) results in a substantial (approximately equal to 40 degrees) bend in the double helix at the intrastrand crosslink between the N7 atoms of adjacent guanosine nucleosides, which bond to the platinum...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Rice, J A, Crothers, D M, Pinto, A L, Lippard, S J
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1988
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280385/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3380785/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.12.4158
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