The major adduct of the antitumor drug cis-diamminedichloroplatinum(II) with DNA bends the duplex by approximately equal to 40 degrees toward the major groove.

We used gel electrophoresis methods to show that reaction of DNA with cis-diamminedichloroplatinum(II) results in a substantial (approximately equal to 40 degrees) bend in the double helix at the intrastrand crosslink between the N7 atoms of adjacent guanosine nucleosides, which bond to the platinum...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Rice, J A, Crothers, D M, Pinto, A L, Lippard, S J
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1988
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280385/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3380785/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.12.4158
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