Dynamics of trimethoprim bound to dihydrofolate reductase.

The conformation of a small molecule in its binding site on a protein is a major factor in the specificity of the interaction between them. In this paper, we report the use of 1H and 13C NMR spectroscopy to study the fluctuations in conformation of the anti-bacterial drug trimethoprim when it is bou...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Searle, M S, Forster, M J, Birdsall, B, Roberts, G C, Feeney, J, Cheung, H T, Kompis, I, Geddes, A J
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1988
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280304/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3131763/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.11.3787
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