Dynamics of trimethoprim bound to dihydrofolate reductase.

The conformation of a small molecule in its binding site on a protein is a major factor in the specificity of the interaction between them. In this paper, we report the use of 1H and 13C NMR spectroscopy to study the fluctuations in conformation of the anti-bacterial drug trimethoprim when it is bou...

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Hlavní autoři: Searle, M S, Forster, M J, Birdsall, B, Roberts, G C, Feeney, J, Cheung, H T, Kompis, I, Geddes, A J
Médium: Artigo
Jazyk:Inglês
Vydáno: 1988
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC280304/
https://ncbi.nlm.nih.gov/pubmed/3131763
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