Dynamics of trimethoprim bound to dihydrofolate reductase.

The conformation of a small molecule in its binding site on a protein is a major factor in the specificity of the interaction between them. In this paper, we report the use of 1H and 13C NMR spectroscopy to study the fluctuations in conformation of the anti-bacterial drug trimethoprim when it is bou...

Descripció completa

Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Searle, M S, Forster, M J, Birdsall, B, Roberts, G C, Feeney, J, Cheung, H T, Kompis, I, Geddes, A J
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1988
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280304/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3131763/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.11.3787
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!