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Regulatory changes in the formation of chromosomal dihydrofolate reductase causing resistance to trimethoprim.

High resistance to trimethoprim mediated by the several hundredfold overproduction of the drug target enzyme, dihyrofolate reductase, in a clinically isolated Escherichia coli strain, 1810, was cloned onto several vector plasmids and seemed to be comprised of a single dihydrofolate reductase gene, w...

詳細記述

保存先:
書誌詳細
主要な著者: Flensburg, J, Sköld, O
フォーマット: Artigo
言語:Inglês
出版事項: 1984
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC215611/
https://ncbi.nlm.nih.gov/pubmed/6330028
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