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A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(β-TRCP)
The Yes-associated protein (YAP) transcription coactivator is a key regulator of organ size and a candidate human oncogene. YAP is inhibited by the Hippo pathway kinase cascade, at least in part via phosphorylation of Ser 127, which results in YAP 14–3–3 binding and cytoplasmic retention. Here we re...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802193/ https://ncbi.nlm.nih.gov/pubmed/20048001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1843810 |
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