Inherent Anti-amyloidogenic Activity of Human Immunoglobulin γ Heavy Chains

We have previously shown that a subpopulation of naturally occurring human IgGs were cross-reactive against conformational epitopes on pathologic aggregates of Aβ, a peptide that forms amyloid fibrils in the brains of patients with Alzheimer disease, inhibited amyloid fibril growth, and dissociated...

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Bibliografiske detaljer
Main Authors: Adekar, Sharad P., Klyubin, Igor, Macy, Sally, Rowan, Michael J., Solomon, Alan, Dessain, Scott K., O'Nuallain, Brian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801233/
https://ncbi.nlm.nih.gov/pubmed/19889627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.044321
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