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The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

Tumor cells are metabolically reprogrammed to fuel cell proliferation. Most transformed cells take up high levels of glucose and produce ATP through aerobic glycolysis. In cells exhibiting aerobic glycolysis, a significant fraction of glucose carbon is also directed into de novo lipogenesis and nucl...

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Main Authors: Tong, Xuemei, Zhao, Fangping, Mancuso, Anthony, Gruber, Joshua J., Thompson, Craig B.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799883/
https://ncbi.nlm.nih.gov/pubmed/19995986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911316106
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