ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation

Glucose stimulates rodent and human β-cell replication, but the intracellular signaling mechanisms are poorly understood. Carbohydrate response element-binding protein (ChREBP) is a lipogenic glucose-sensing transcription factor with unknown functions in pancreatic β-cells. We tested the hypothesis...

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Detalhes bibliográficos
Main Authors: Metukuri, Mallikarjuna R., Zhang, Pili, Basantani, Mahesh K., Chin, Connie, Stamateris, Rachel E., Alonso, Laura C., Takane, Karen K., Gramignoli, Roberto, Strom, Stephen C., O’Doherty, Robert M., Stewart, Andrew F., Vasavada, Rupangi C., Garcia-Ocaña, Adolfo, Scott, Donald K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402328/
https://ncbi.nlm.nih.gov/pubmed/22586588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0802
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