ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation

Glucose stimulates rodent and human β-cell replication, but the intracellular signaling mechanisms are poorly understood. Carbohydrate response element-binding protein (ChREBP) is a lipogenic glucose-sensing transcription factor with unknown functions in pancreatic β-cells. We tested the hypothesis...

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Détails bibliographiques
Auteurs principaux: Metukuri, Mallikarjuna R., Zhang, Pili, Basantani, Mahesh K., Chin, Connie, Stamateris, Rachel E., Alonso, Laura C., Takane, Karen K., Gramignoli, Roberto, Strom, Stephen C., O’Doherty, Robert M., Stewart, Andrew F., Vasavada, Rupangi C., Garcia-Ocaña, Adolfo, Scott, Donald K.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2012
Sujets:
Islet Studies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402328/
https://ncbi.nlm.nih.gov/pubmed/22586588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0802
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