ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation

Glucose stimulates rodent and human β-cell replication, but the intracellular signaling mechanisms are poorly understood. Carbohydrate response element-binding protein (ChREBP) is a lipogenic glucose-sensing transcription factor with unknown functions in pancreatic β-cells. We tested the hypothesis...

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Hlavní autoři: Metukuri, Mallikarjuna R., Zhang, Pili, Basantani, Mahesh K., Chin, Connie, Stamateris, Rachel E., Alonso, Laura C., Takane, Karen K., Gramignoli, Roberto, Strom, Stephen C., O’Doherty, Robert M., Stewart, Andrew F., Vasavada, Rupangi C., Garcia-Ocaña, Adolfo, Scott, Donald K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2012
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402328/
https://ncbi.nlm.nih.gov/pubmed/22586588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0802
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