ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation

Glucose stimulates rodent and human β-cell replication, but the intracellular signaling mechanisms are poorly understood. Carbohydrate response element-binding protein (ChREBP) is a lipogenic glucose-sensing transcription factor with unknown functions in pancreatic β-cells. We tested the hypothesis...

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Autors principals: Metukuri, Mallikarjuna R., Zhang, Pili, Basantani, Mahesh K., Chin, Connie, Stamateris, Rachel E., Alonso, Laura C., Takane, Karen K., Gramignoli, Roberto, Strom, Stephen C., O’Doherty, Robert M., Stewart, Andrew F., Vasavada, Rupangi C., Garcia-Ocaña, Adolfo, Scott, Donald K.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2012
Matèries:
Islet Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402328/
https://ncbi.nlm.nih.gov/pubmed/22586588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0802
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