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Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation
Carbohydrate-responsive element–binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic β-cells in rodents and humans. The full-length isoform (ChREBPα) has a low glucose inhibitory domain (LID) that restrains the transactivation...
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| Publicado en: | Diabetes |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Diabetes Association
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4657577/ https://ncbi.nlm.nih.gov/pubmed/26384380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0239 |
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