Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation

Carbohydrate-responsive element–binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic β-cells in rodents and humans. The full-length isoform (ChREBPα) has a low glucose inhibitory domain (LID) that restrains the transactivation...

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Vydáno v:Diabetes
Hlavní autoři: Zhang, Pili, Kumar, Anil, Katz, Liora S., Li, Lucy, Paulynice, Martine, Herman, Mark A., Scott, Donald K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2015
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657577/
https://ncbi.nlm.nih.gov/pubmed/26384380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0239
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