The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

Tumor cells are metabolically reprogrammed to fuel cell proliferation. Most transformed cells take up high levels of glucose and produce ATP through aerobic glycolysis. In cells exhibiting aerobic glycolysis, a significant fraction of glucose carbon is also directed into de novo lipogenesis and nucl...

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Bibliographic Details
Main Authors: Tong, Xuemei, Zhao, Fangping, Mancuso, Anthony, Gruber, Joshua J., Thompson, Craig B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799883/
https://ncbi.nlm.nih.gov/pubmed/19995986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911316106
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