Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

The nature of the in vivo cellular events underlying thrombus formation mediated by platelet activation remains unclear because of the absence of a modality for analysis. Lymphocyte adaptor protein (Lnk; also known as Sh2b3) is an adaptor protein that inhibits thrombopoietin-mediated signaling, and...

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Detalhes bibliográficos
Main Authors: Takizawa, Hitoshi, Nishimura, Satoshi, Takayama, Naoya, Oda, Atsushi, Nishikii, Hidekazu, Morita, Yohei, Kakinuma, Sei, Yamazaki, Satoshi, Okamura, Satoshi, Tamura, Noriko, Goto, Shinya, Sawaguchi, Akira, Manabe, Ichiro, Takatsu, Kiyoshi, Nakauchi, Hiromitsu, Takaki, Satoshi, Eto, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798683/
https://ncbi.nlm.nih.gov/pubmed/20038804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39503
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