Multicolor Staining of Globin Subtypes Reveals Impaired Globin Switching During Erythropoiesis in Human Pluripotent Stem Cells

Adult hemoglobin composed of α- and β-globin reflects a change from expression of embryonic ε- and fetal γ-globin to adult β-globin in human erythroid cells, so-called globin switching. Human pluripotent stem cells (hPSCs) are a potential source for in vitro erythrocyte production, but they show pro...

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Bibliographic Details
Main Authors: Ochi, Kiyosumi, Takayama, Naoya, Hirose, Shoichi, Nakahata, Tatsutoshi, Nakauchi, Hiromitsu, Eto, Koji
Format: Artigo
Language:Inglês
Published: AlphaMed Press 2014
Subjects:
Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073826/
https://ncbi.nlm.nih.gov/pubmed/24873860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2013-0216
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