Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance

OBJECTIVE: To investigate the role of the endoplasmic reticulum (ER) chaperone glucose-regulated protein (GRP) 78/BiP in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. RESEARCH DESIGN AND METHODS: Male Grp78(+/−) mice and their wild-type littermates were subjected to a high-fa...

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Bibliografiske detaljer
Main Authors: Ye, Risheng, Jung, Dae Young, Jun, John Y., Li, Jianze, Luo, Shengzhan, Ko, Hwi Jin, Kim, Jason K., Lee, Amy S.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2010
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797945/
https://ncbi.nlm.nih.gov/pubmed/19808896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0755
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