Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

Neurodegenerative diseases are often associated with dysfunction in protein quality control. The endoplasmic reticulum (ER), a key site for protein synthesis, senses stressful conditions by activating the unfolded protein response (UPR). Here we report the creation of a novel mouse model where GRP78...

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Autors principals: Wang, Miao, Ye, Risheng, Barron, Ernesto, Baumeister, Peter, Mao, Changhui, Luo, Shengzhan, Fu, Yong, Luo, Biquan, Dubeau, Louis, Hinton, David R., Lee, Amy S.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822118/
https://ncbi.nlm.nih.gov/pubmed/19816510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2009.144
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