Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

Neurodegenerative diseases are often associated with dysfunction in protein quality control. The endoplasmic reticulum (ER), a key site for protein synthesis, senses stressful conditions by activating the unfolded protein response (UPR). Here we report the creation of a novel mouse model where GRP78...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wang, Miao, Ye, Risheng, Barron, Ernesto, Baumeister, Peter, Mao, Changhui, Luo, Shengzhan, Fu, Yong, Luo, Biquan, Dubeau, Louis, Hinton, David R., Lee, Amy S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822118/
https://ncbi.nlm.nih.gov/pubmed/19816510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2009.144
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