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Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis
Neurodegenerative diseases are often associated with dysfunction in protein quality control. The endoplasmic reticulum (ER), a key site for protein synthesis, senses stressful conditions by activating the unfolded protein response (UPR). Here we report the creation of a novel mouse model where GRP78...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822118/ https://ncbi.nlm.nih.gov/pubmed/19816510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2009.144 |
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