Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity

Obesity-mediated inflammation is a major cause of insulin resistance, and macrophages play an important role in this process. The 78-kDa glucose-regulated protein (GRP78) is a major endoplasmic reticulum chaperone that modulates unfolded protein response (UPR), and mice with GRP78 heterozygosity wer...

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Bibliografiska uppgifter
I publikationen:FASEB J
Huvudupphovsmän: Kim, Jong Hun, Lee, Eunjung, Friedline, Randall H., Suk, Sujin, Jung, Dae Young, Dagdeviren, Sezin, Hu, Xiaodi, Inashima, Kunikazu, Noh, Hye Lim, Kwon, Jung Yeon, Nambu, Aya, Huh, Jun R., Han, Myoung Sook, Davis, Roger J., Lee, Amy S., Lee, Ki Won, Kim, Jason K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Federation of American Societies for Experimental Biology 2018
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207176/
https://ncbi.nlm.nih.gov/pubmed/29242277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701017R
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