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A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis

An accumulation of misfolded proteins can trigger a cellular survival response in the endoplasmic reticulum (ER). In this study, we found that ER stress–associated gene signatures were highly expressed in rheumatoid arthritis (RA) synoviums and synovial cells. Proinflammatory cytokines, such as TNF...

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Main Authors: Yoo, Seung-Ah, You, Sungyong, Yoon, Hyung-Ju, Kim, Dong-Ho, Kim, Hyun-Sook, Lee, Kyungho, Ahn, Jin Hee, Hwang, Daehee, Lee, Amy S., Kim, Ki-Jo, Park, Yune-Jung, Cho, Chul-Soo, Kim, Wan-Uk
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328363/
https://ncbi.nlm.nih.gov/pubmed/22430489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111783
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