A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis

An accumulation of misfolded proteins can trigger a cellular survival response in the endoplasmic reticulum (ER). In this study, we found that ER stress–associated gene signatures were highly expressed in rheumatoid arthritis (RA) synoviums and synovial cells. Proinflammatory cytokines, such as TNF...

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Autores principales: Yoo, Seung-Ah, You, Sungyong, Yoon, Hyung-Ju, Kim, Dong-Ho, Kim, Hyun-Sook, Lee, Kyungho, Ahn, Jin Hee, Hwang, Daehee, Lee, Amy S., Kim, Ki-Jo, Park, Yune-Jung, Cho, Chul-Soo, Kim, Wan-Uk
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328363/
https://ncbi.nlm.nih.gov/pubmed/22430489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111783
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