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Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein–ligand X-ray studies

Recently, we designed a series of novel HIV-1 protease inhibitors incorporating a stereochemically defined bicyclic fused cyclopentyl (Cp-THF) urethane as the high affinity P2-ligand. Inhibitor 1 with this P2-ligand has shown very impressive potency against multi-drug-resistant clinical isolates. Ba...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ghosh, Arun K., Gemma, Sandra, Takayama, Jun, Baldridge, Abigail, Leshchenko-Yashchuk, Sofiya, Miller, Heather B., Wang, Yuan-Fang, Kovalevsky, Andrey Y., Koh, Yashiro, Weber, Irene T., Mitsuya, Hiroaki
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2008
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797486/
https://ncbi.nlm.nih.gov/pubmed/18843400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b809178a
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