Synthesis and Biological Evaluation of Novel Allophenylnorstatine-based HIV-1 Protease Inhibitors Incorporating High Affinity P2-ligands

A series of stereochemically defined cyclic ethers as P2-ligands were incorporated in an allophenylnorstatine-based isostere to provide a new series of HIV-1 protease inhibitors. Inhibitors 3b and 3c, containing conformationally constrained cyclic ethers, displayed impressive enzymatic and antiviral...

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Hlavní autoři: Ghosh, Arun K., Gemma, Sandra, Simoni, Elena, Baldridge, Abigail, Walters, D. Eric, Ide, Kazuhiko, Tojo, Yasushi, Koh, Yasuhiro, Amano, Masayuki, Mitsuya, Hiroaki
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179850/
https://ncbi.nlm.nih.gov/pubmed/20034787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.11.123
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