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Design and Synthesis of Stereochemically Defined Novel Spirocyclic P2-Ligands for HIV-1 Protease Inhibitors

[Image: see text] The synthesis of a series of stereochemically defined spirocyclic compounds and their use as novel P2-ligands for HIV-1 protease inhibitors are described. The bicyclic core of the ligands was synthesized by an efficient nBu(3)SnH-promoted radical cyclization of a 1,6-enyne followed...

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Detalhes bibliográficos
Main Authors: Ghosh, Arun K., Chapsal, Bruno D., Baldridge, Abigail, Ide, Kazuhiko, Koh, Yashiro, Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745598/
https://ncbi.nlm.nih.gov/pubmed/18928291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol8020308
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