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Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation and Protein-ligand X-ray Studies

We report the design, synthesis and biological evaluation of a series of novel HIV-1 protease inhibitors. The inhibitors incorporate stereochemically defined flexible cyclic ethers/polyethers as the high affinity P2-ligands. Inhibitors containing small ring 1,3-dioxacycloalkanes have shown potent en...

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Bibliografische gegevens
Hoofdauteurs: Ghosh, Arun K., Gemma, Sandra, Baldridge, Abigail, Wang, Yuan-Fang, Kovalevsky, Andrey Yu., Koh, Yashiro, Weber, Irene T., Mitsuya, Hiroaki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812926/
https://ncbi.nlm.nih.gov/pubmed/18783203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8004543
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