Design, Synthesis, Protein-ligand X-ray Structures and Biological Evaluation of a Series of Novel Macrocyclic HIV-1 Protease Inhibitors to Combat Drug-resistance

The structure-based design, synthesis and biological evaluation of a series of nonpeptidic macrocyclic HIV protease inhibitors are described. The inhibitors are designed to effectively fill in the hydrophobic pocket in the S1′ S2′ subsites and retain all major hydrogen bonding with the protein backb...

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Detalhes bibliográficos
Main Authors: Ghosh, Arun K., Kulkarni, Sarang, Anderson, David D., Hong, Lin, Baldridge, Abigail, Wang, Yuan-Fang, Chumanevich, Alexander A., Kovalevsky, Andrey Y., Tojo, Yasushi, Koh, Yasuhiro, Tang, Jordan, Weber, Irene T., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943150/
https://ncbi.nlm.nih.gov/pubmed/19746963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900695w
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