Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1’-Ligands to Enhance Backbone-binding interactions with Protease: Synthesis, Biological Evaluation and Protein-ligand X-ray Studies

Structure-based design, synthesis and biological evaluation of a series of novel HIV-1 protease inhibitors are described. In an effort to enhance interactions with protease backbone atoms, we have incorporated stereochemically defined methyl-2-pyrrolidinone and methyl oxazolidinone as the P1′-ligand...

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Hlavní autoři: Ghosh, Arun K., Leshchenko-Yashchuk, Sofiya, Anderson, David D., Baldridge, Abigail, Noetzel, Marcus, Miller, Heather B., Tie, Yunfeng, Wang, Yuan-Fang, Koh, Yasuhiro, Weber, Irene T., Mitsuya, Hiroaki
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745609/
https://ncbi.nlm.nih.gov/pubmed/19473017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900303m
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