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Design and Synthesis of Stereochemically Defined Novel Spirocyclic P2-Ligands for HIV-1 Protease Inhibitors
[Image: see text] The synthesis of a series of stereochemically defined spirocyclic compounds and their use as novel P2-ligands for HIV-1 protease inhibitors are described. The bicyclic core of the ligands was synthesized by an efficient nBu(3)SnH-promoted radical cyclization of a 1,6-enyne followed...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745598/ https://ncbi.nlm.nih.gov/pubmed/18928291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol8020308 |
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