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Novel Positive Feedback Loop between Cdk1 and Chk1 in the Nucleus during G(2)/M Transition
Chk1, one of the critical transducers in DNA damage/replication checkpoints, prevents entry into mitosis through inhibition of Cdk1 activity. However, it has remained unclear how this inhibition is cancelled at the G(2)/M transition. We reported recently that Chk1 is phosphorylated at Ser(286) and S...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797192/ https://ncbi.nlm.nih.gov/pubmed/19837665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C109.051540 |
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