14-3-3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage

14-3-3 proteins control various cellular processes, including cell cycle progression and DNA damage checkpoint. At the DNA damage checkpoint, some subtypes of 14-3-3 (β and ζ isoforms in mammalian cells and Rad24 in fission yeast) bind to Ser345-phosphorylated Chk1 and promote its nuclear retention....

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Hlavní autoři: Kasahara, Kousuke, Goto, Hidemasa, Enomoto, Masato, Tomono, Yasuko, Kiyono, Tohru, Inagaki, Masaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924644/
https://ncbi.nlm.nih.gov/pubmed/20639859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.157
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