PI 3-kinase-dependent phosphorylation of Plk1–Ser99 promotes association with 14-3-3γ and is required for metaphase–anaphase transition

Polo-like kinase 1 (Plk1) controls multiple aspects of mitosis and is activated through its phosphorylation at Thr210. Here we identify Ser99 on Plk1 as a novel mitosis-specific phosphorylation site, which operates independently of Plk1–Thr210 phosphorylation. Plk1–Ser99 phosphorylation creates a do...

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Autori principali: Kasahara, Kousuke, Goto, Hidemasa, Izawa, Ichiro, Kiyono, Tohru, Watanabe, Nobumoto, Elowe, Sabine, Nigg, Erich A, Inagaki, Masaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675326/
https://ncbi.nlm.nih.gov/pubmed/23695676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2879
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