Novel Positive Feedback Loop between Cdk1 and Chk1 in the Nucleus during G(2)/M Transition

Chk1, one of the critical transducers in DNA damage/replication checkpoints, prevents entry into mitosis through inhibition of Cdk1 activity. However, it has remained unclear how this inhibition is cancelled at the G(2)/M transition. We reported recently that Chk1 is phosphorylated at Ser(286) and S...

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Библиографические подробности
Главные авторы: Enomoto, Masato, Goto, Hidemasa, Tomono, Yasuko, Kasahara, Kousuke, Tsujimura, Kunio, Kiyono, Tohru, Inagaki, Masaki
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2009
Предметы:
Mechanisms of Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797192/
https://ncbi.nlm.nih.gov/pubmed/19837665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C109.051540
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