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Molecular Modeling of the Misfolded Insulin Subunit and Amyloid Fibril

Insulin, a small hormone protein comprising 51 residues in two disulfide-linked polypeptide chains, adopts a predominantly α-helical conformation in its native state. It readily undergoes protein misfolding and aggregates into amyloid fibrils under a variety of conditions. Insulin is a unique model...

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Bibliografske podrobnosti
Main Authors: Choi, Jay H., May, Barnaby C.H., Wille, Holger, Cohen, Fred E.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793351/
https://ncbi.nlm.nih.gov/pubmed/20006956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.09.042
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