Misfolded Amyloid Ion Channels Present Mobile β-Sheet Subunits in Contrast to Conventional Ion Channels

In Alzheimer's disease, calcium permeability through cellular membranes appears to underlie neuronal cell death. It is increasingly accepted that calcium permeability involves toxic ion channels. We modeled Alzheimer's disease ion channels of different sizes (12-mer to 36-mer) in the lipid...

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Hlavní autoři: Jang, Hyunbum, Arce, Fernando Teran, Capone, Ricardo, Ramachandran, Srinivasan, Lal, Ratnesh, Nussinov, Ruth
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2009
Témata:
Protein
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784570/
https://ncbi.nlm.nih.gov/pubmed/19948133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.09.014
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