Misfolded Amyloid Ion Channels Present Mobile β-Sheet Subunits in Contrast to Conventional Ion Channels

In Alzheimer's disease, calcium permeability through cellular membranes appears to underlie neuronal cell death. It is increasingly accepted that calcium permeability involves toxic ion channels. We modeled Alzheimer's disease ion channels of different sizes (12-mer to 36-mer) in the lipid...

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Detalhes bibliográficos
Main Authors: Jang, Hyunbum, Arce, Fernando Teran, Capone, Ricardo, Ramachandran, Srinivasan, Lal, Ratnesh, Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784570/
https://ncbi.nlm.nih.gov/pubmed/19948133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.09.014
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