Misfolded Amyloid Ion Channels Present Mobile β-Sheet Subunits in Contrast to Conventional Ion Channels

In Alzheimer's disease, calcium permeability through cellular membranes appears to underlie neuronal cell death. It is increasingly accepted that calcium permeability involves toxic ion channels. We modeled Alzheimer's disease ion channels of different sizes (12-mer to 36-mer) in the lipid...

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Détails bibliographiques
Auteurs principaux: Jang, Hyunbum, Arce, Fernando Teran, Capone, Ricardo, Ramachandran, Srinivasan, Lal, Ratnesh, Nussinov, Ruth
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2009
Sujets:
Protein
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784570/
https://ncbi.nlm.nih.gov/pubmed/19948133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.09.014
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