All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers

Alzheimer’s disease (AD) is the most common type of senile dementia in aging populations. Amyloid β (Aβ)-mediated dysregulation of ionic homeostasis is the prevailing underlying mechanism leading to synaptic degeneration and neuronal death. Aβ-dependent ionic dysregulation most likely occurs either...

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Main Authors: Capone, Ricardo, Jang, Hyunbum, Kotler, Samuel A., Connelly, Laura, Teran Arce, Fernando, Ramachandran, Srinivasan, Kagan, Bruce L., Nussinov, Ruth, Lal, Ratnesh
Format: Artigo
Language:Inglês
Published: American Chemical Society 2012
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302213/
https://ncbi.nlm.nih.gov/pubmed/22423218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct200885r
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