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Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane

Amyloid-β (Aβ) oligomers destabilize cellular ionic homeostasis, mediating Alzheimer's disease (AD). It is still unclear whether the mechanism (i) is mediated by cell surface receptors; (ii) is direct, with Aβ oligomers interacting with membrane lipids; or (iii) both mechanisms take place. Rece...

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Detalhes bibliográficos
Main Authors: Jang, Hyunbum, Connelly, Laura, Arce, Fernando Teran, Ramachandran, Srinivasan, Kagan, Bruce L., Lal, Ratnesh, Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539805/
https://ncbi.nlm.nih.gov/pubmed/23316126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct300916f
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