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β-Barrel Topology of Alzheimer’s β-Amyloid Ion Channels
Emerging evidence supports the ion channel mechanism for Alzheimer’s disease pathophysiology wherein small β-amyloid (Aβ) oligomers insert into the cell membrane, forming toxic ion channels and destabilizing the cellular ionic homeostasis. Solid-state NMR-based data of amyloid oligomers in solution...
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| Udgivet i: | J Mol Biol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7291702/ https://ncbi.nlm.nih.gov/pubmed/20970427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.10.025 |
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