β-Barrel Topology of Alzheimer’s β-Amyloid Ion Channels

Emerging evidence supports the ion channel mechanism for Alzheimer’s disease pathophysiology wherein small β-amyloid (Aβ) oligomers insert into the cell membrane, forming toxic ion channels and destabilizing the cellular ionic homeostasis. Solid-state NMR-based data of amyloid oligomers in solution...

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Udgivet i:J Mol Biol
Main Authors: Jang, Hyunbum, Arce, Fernando Teran, Ramachandran, Srinivasan, Capone, Ricardo, Lal, Ratnesh, Nussinov, Ruth
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7291702/
https://ncbi.nlm.nih.gov/pubmed/20970427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.10.025
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