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Atomic Force Microscopy and MD Simulations Reveal Pore-Like Structures of All-D-Enantiomer of Alzheimer’s β-Amyloid Peptide: Relevance to the Ion Channel Mechanism of AD Pathology

Alzheimer’s disease (AD) is a protein misfolding disease characterized by a build-up of β-amyloid (Aβ) peptide as senile plaques, uncontrolled neurodegeneration, and memory loss. AD pathology is linked to the destabilization of cellular ionic homeostasis and involves Aβ peptide-plasma membrane inter...

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Detaylı Bibliyografya
Yayımlandı:J Phys Chem B
Asıl Yazarlar: Connelly, Laura, Arce, Fernando Teran, Jang, Hyunbum, Capone, Ricardo, Kotler, Samuel A., Ramachandran, Srinivasan, Kagan, Bruce L., Nussinov, Ruth, Lal, Ratnesh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342054/
https://ncbi.nlm.nih.gov/pubmed/22217000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp2108126
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