TRPM2-mediated Ca(2+) influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxi...

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Detalhes bibliográficos
Main Authors: Yamamoto, Shinichiro, Shimizu, Shunichi, Kiyonaka, Shigeki, Takahashi, Nobuaki, Wajima, Teruaki, Hara, Yuji, Negoro, Takaharu, Hiroi, Toshihito, Kiuchi, Yuji, Okada, Takaharu, Kaneko, Shuji, Lange, Ingo, Fleig, Andrea, Penner, Reinhold, Nishi, Miyuki, Takeshima, Hiroshi, Mori, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789807/
https://ncbi.nlm.nih.gov/pubmed/18542050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1758
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